1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine → HCID 71251967, compound

HRID 2411578Notes

Reaction equation

HRID 2411578 reaction equation
[O:1]=[S:2]1(=[O:23])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:16]=[CH:15][C:10]([C:11]([O:13]C)=O)=[C:9]([N:17]2[CH2:21][CH2:20][O:19][C:18]2=[O:22])[CH:8]=1.[CH:24]1([C:27]2[CH:28]=[C:29]([CH3:39])[C:30]([N:33]3[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]3)=[N:31][CH:32]=2)[CH2:26][CH2:25]1>>[CH:24]1([C:27]2[CH:28]=[C:29]([CH3:39])[C:30]([N:33]3[CH2:34][CH2:35][N:36]([C:11]([C:10]4[CH:15]=[CH:16][C:7]([N:3]5[CH2:4][CH2:5][CH2:6][S:2]5(=[O:1])=[O:23])=[CH:8][C:9]=4[N:17]4[CH2:21][CH2:20][O:19][C:18]4=[O:22])=[O:13])[CH2:37][CH2:38]3)=[N:31][CH:32]=2)[CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazineHCID 71251904HCID 71251904, compound

Product 1

HCID 71251967HCID 71251967, compoundYield 9.5%

Procedure

Using methyl 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-(2-oxooxazolidin-3-yl)benzoate (170 mg) described in Preparation Example 32 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (110 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109, the title compound (25 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-6e4541ce23744777a698b56e206aa4e5
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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