1-(3,5-Dimethylpyridin-2-yl)piperazine → HCID 71252620, compound

HRID 2411579Notes

Reaction equation

HRID 2411579 reaction equation
[O:1]=[S:2]1(=[O:23])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:16]=[CH:15][C:10]([C:11](OC)=[O:12])=[C:9]([N:17]2[CH2:21][CH2:20][CH2:19][C:18]2=[O:22])[CH:8]=1.[CH3:24][C:25]1[C:26]([N:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)=[N:27][CH:28]=[C:29]([CH3:31])[CH:30]=1>>[CH3:24][C:25]1[C:26]([N:32]2[CH2:33][CH2:34][N:35]([C:11]([C:10]3[CH:15]=[CH:16][C:7]([N:3]4[CH2:4][CH2:5][CH2:6][S:2]4(=[O:1])=[O:23])=[CH:8][C:9]=3[N:17]3[CH2:21][CH2:20][CH2:19][C:18]3=[O:22])=[O:12])[CH2:36][CH2:37]2)=[N:27][CH:28]=[C:29]([CH3:31])[CH:30]=1

Participants

3

Reactant 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazineHCID 71252731HCID 71252731, compound

Product 1

HCID 71252620HCID 71252620, compoundYield 2.3%

Procedure

Using methyl 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-(2-oxopyrrolidin-1-yl)benzoate (148 mg) described in Preparation Example 33 and 1-(3,5-dimethylpyridin-2-yl)piperazine (84 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109, the title compound (5 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-f3d5a3fb5c9b4a0ba113cd204f8ce355
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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