HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Butanesultam → [4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-[1,2]thiazinan-2-yl)phenyl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Butanesultam | HCID 303508 | — |
| Reactant | (4-Bromophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone | HCID 71252046 | — |
| Product | [4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-[1,2]thiazinan-2-yl)phenyl]methanone | HCID 71252529 | 55.1% |
Reaction Steps
Using (4-bromophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (187 mg) described in Preparation Example 165 and [1,2]thiazinane 1,1-dioxide (68 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (118 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-d185aceaeff0440f8f3fb50310741e26 |
| Source note | uspto-grants-2014_08 |