4-(1,1-Dioxo-1,2-thiazolidin-2-yl)benzoic acid → HCID 71251928, compound

HRID 2411588Notes

Reaction equation

HRID 2411588 reaction equation
[O:1]=[S:2]1(=[O:16])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][CH:8]=1.[CH3:17][C:18]1[CH:19]=[C:20]([CH:25]=[CH:26][C:27]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1)[C:21]([O:23][CH3:24])=[O:22]>>[O:16]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:8]=[CH:9][C:10]([C:11]([N:31]2[CH2:30][CH2:29][N:28]([C:27]3[CH:26]=[CH:25][C:20]([C:21]([O:23][CH3:24])=[O:22])=[CH:19][C:18]=3[CH3:17])[CH2:33][CH2:32]2)=[O:13])=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 66250114-(1,1-Dioxo-1,2-thiazolidin-2-yl)benzoic acidHCID 71253188HCID 71253188, compound

Product 1

HCID 71251928HCID 71251928, compoundYield 77.6%

Procedure

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)benzoic acid (1.08 g) described in Preparation Example 16 and methyl 3-methyl-4-(piperazin-1-yl)benzoate (1.05 g) described in Preparation Example 97 and by the reaction and treatment in the same manner as in Example 87, the title compound (1.59 g) was obtained.

Workup

  1. customdescribed in Preparation Example 97 and by the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-2a866f56af024efb9068770ec463e648
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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