4-(1,1-Dioxo-1,2-thiazolidin-2-yl)benzoic acid → HCID 71252023, compound

HRID 2411590Notes

Reaction equation

HRID 2411590 reaction equation
[O:1]=[S:2]1(=[O:16])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][CH:8]=1.[CH3:17][C:18]1[CH:19]=[C:20]([CH2:30][OH:31])[CH:21]=[CH:22][C:23]=1[N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>>[O:16]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:8]=[CH:9][C:10]([C:11]([N:27]2[CH2:26][CH2:25][N:24]([C:23]3[CH:22]=[CH:21][C:20]([CH2:30][OH:31])=[CH:19][C:18]=3[CH3:17])[CH2:29][CH2:28]2)=[O:13])=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 66250114-(1,1-Dioxo-1,2-thiazolidin-2-yl)benzoic acidHCID 64366284HCID 64366284, compound

Product 1

HCID 71252023HCID 71252023, compoundYield 52.2%

Procedure

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)benzoic acid (378 mg) described in Preparation Example 16 and [3-methyl-4-(piperazin-1-yl)phenyl]methanol (323 mg) described in Preparation Example 98 and by the reaction and treatment in the same manner as in Example 87, the title compound (351 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 98 and by the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-813ff5aa275841dab8aff8ca87a9a25d
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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