4-(1,1-Dioxo-1,2-thiazolidin-2-yl)benzoic acid → HCID 71252538, compound

HRID 2411591Notes

Reaction equation

HRID 2411591 reaction equation
[O:1]=[S:2]1(=[O:16])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][CH:8]=1.[CH3:17][C:18]1[CH:19]=[CH:20][C:21]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[C:22]([CH2:24][OH:25])[CH:23]=1>>[O:16]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:8]=[CH:9][C:10]([C:11]([N:29]2[CH2:28][CH2:27][N:26]([C:21]3[CH:20]=[CH:19][C:18]([CH3:17])=[CH:23][C:22]=3[CH2:24][OH:25])[CH2:31][CH2:30]2)=[O:13])=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 66250114-(1,1-Dioxo-1,2-thiazolidin-2-yl)benzoic acidHCID 71252079HCID 71252079, compound

Product 1

HCID 71252538HCID 71252538, compoundYield 27%

Procedure

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)benzoic acid (550 mg) described in Preparation Example 16 and [5-methyl-2-(piperazin-1-yl)phenyl]methanol (470 mg) described in Preparation Example 99 and by the reaction and treatment in the same manner as in Example 87, the title compound (264 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 99 and by the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-b453053bc9bd469680f30ade7939c010
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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