Ammonia → HCID 71252307, compound

HRID 2411592Notes

Reaction equation

HRID 2411592 reaction equation
[O:1]=[S:2]1(=[O:31])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:30]=[CH:29][C:10]([C:11]([N:13]2[CH2:18][CH2:17][N:16]([C:19]3[CH:27]=[CH:26][C:22]([C:23](O)=[O:24])=[CH:21][C:20]=3[CH3:28])[CH2:15][CH2:14]2)=[O:12])=[CH:9][CH:8]=1.[NH3:32]>>[O:1]=[S:2]1(=[O:31])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:8]=[CH:9][C:10]([C:11]([N:13]2[CH2:14][CH2:15][N:16]([C:19]3[CH:27]=[CH:26][C:22]([C:23]([NH2:32])=[O:24])=[CH:21][C:20]=3[CH3:28])[CH2:17][CH2:18]2)=[O:12])=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 71252574HCID 71252574, compound

Product 1

HCID 71252307HCID 71252307, compound

Procedure

Using 4-{4-[4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)benzoyl]piperazin-1-yl}-3-methylbenzoic acid (200 mg) described in Example 218 and 28% aqueous ammonia (5 mL) and by the reaction and treatment in the same manner as in Example 220, the title compound (68 mg) was obtained.

Sources & evidence

ORD record
ord-6b0401dd9f294dfea90a562d48d999eb
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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