HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Cyclopropyl-5-methylpyridin-2-yl)piperazine → [4-(3-Cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl][6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)pyridin-3-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Cyclopropyl-5-methylpyridin-2-yl)piperazine | HCID 58484621 | — |
| Reactant | Ethyl 6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)nicotinate | HCID 71251937 | — |
| Product | [4-(3-Cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl][6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)pyridin-3-yl]methanone | HCID 71252490 | 45.9% |
Reaction Steps
Using ethyl 6-(1,1-dioxo-1λ6-isothiazolidin-2-yl)nicotinate (300 mg) described in Preparation Example 25 and 1-(3-cyclopropyl-5-methylpyridin-2-yl)piperazine (241 mg) described in Preparation Example 86 and by the reaction and treatment in the same manner as in Example 109, the title compound (225 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-922f3a47846446d5b08ab6bee9bca724 |
| Source note | uspto-grants-2014_08 |