1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine → [4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl][6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)pyridin-3-yl]methanone

Participants

Reaction Steps

Using ethyl 6-(1,1-dioxo-1λ6-isothiazolidin-2-yl)nicotinate (194 mg) described in Preparation Example 25 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (170 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109, the title compound (95 mg) was obtained.

Provenance & Evidence