3-Chloropropanesulphonyl chloride → [4-(3-Cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl][6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-4-methylpyridin-3-yl]methanone

Participants

Reaction Steps

Using [4-(3-cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone (180 mg) described in Preparation Example 181, 4-methoxybenzylamine (2 mL) and 3-chloropropane-1-sulfonyl chloride (0.12 mL) and by the reaction and treatment in the same manner as in Example 229, the title compound (125 mg) was obtained via (6-amino-4-methylpyridin-3-yl)[4-(3-cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl]methanone.

Provenance & Evidence