1-(5-Ethyl-3-methylpyridin-2-yl)piperazine → HCID 71252575, compound

HRID 2411613Notes

Reaction equation

HRID 2411613 reaction equation
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:16]=[CH:15][C:10]([C:11]([O:13]C)=O)=[C:9]([CH3:17])[N:8]=1.[CH2:19]([C:21]1[CH:22]=[C:23]([CH3:33])[C:24]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[N:25][CH:26]=1)[CH3:20]>>[O:18]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[N:8]=[C:9]([CH3:17])[C:10]([C:11]([N:30]2[CH2:31][CH2:32][N:27]([C:24]3[C:23]([CH3:33])=[CH:22][C:21]([CH2:19][CH3:20])=[CH:26][N:25]=3)[CH2:28][CH2:29]2)=[O:13])=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 584845781-(5-Ethyl-3-methylpyridin-2-yl)piperazineHCID 71252256HCID 71252256, compound

Product 1

HCID 71252575HCID 71252575, compoundYield 5.1%

Procedure

Using methyl 6-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-methylnicotinate (300 mg) described in Preparation Example 37 and 1-(5-ethyl-3-methylpyridin-2-yl)piperazine (251 mg) described in Preparation Example 81 and by the reaction and treatment in the same manner as in Example 109, the title compound (25 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 81 and by the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-f1716edaabfa4f969169ae9e6915e255
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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