HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3,5-Dimethylpyridin-2-yl)piperazine → (R)-[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl][4-(3-methyl-1,1-dioxo-1lambda6-isothiazolidin-2-ylmethyl)phenyl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3,5-Dimethylpyridin-2-yl)piperazine | HCID 58484496 | — |
| Reactant | methyl (R)-4-(3-methyl-1,1-dioxo-1lambda6-isothiazolidin-2-ylmethyl)benzoate | HCID 71261169 | — |
| Product | (R)-[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl][4-(3-methyl-1,1-dioxo-1lambda6-isothiazolidin-2-ylmethyl)phenyl]methanone | HCID 71252277 | 78.3% |
Reaction Steps
Using methyl (R)-4-(3-methyl-1,1-dioxo-1λ6-isothiazolidin-2-ylmethyl)benzoate (79 mg) described in Preparation Example 42 and 1-(3,5-dimethylpyridin-2-yl)piperazine (53 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109, the title compound (96 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-b129462cb75344c8b1108c316275ca77 |
| Source note | uspto-grants-2014_08 |