1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine → HCID 71252161, compound

HRID 2411626Notes

Reaction equation

HRID 2411626 reaction equation
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C@H:7]([C:9]1[CH:17]=[CH:16][C:12]([C:13]([OH:15])=O)=[CH:11][CH:10]=1)[CH3:8].[CH:19]1([C:22]2[CH:23]=[C:24]([CH3:34])[C:25]([N:28]3[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]3)=[N:26][CH:27]=2)[CH2:21][CH2:20]1>>[CH:19]1([C:22]2[CH:23]=[C:24]([CH3:34])[C:25]([N:28]3[CH2:29][CH2:30][N:31]([C:13]([C:12]4[CH:11]=[CH:10][C:9]([C@@H:7]([N:3]5[CH2:4][CH2:5][CH2:6][S:2]5(=[O:1])=[O:18])[CH3:8])=[CH:17][CH:16]=4)=[O:15])[CH2:32][CH2:33]3)=[N:26][CH:27]=2)[CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazineHCID 71251858HCID 71251858, compound

Product 1

HCID 71252161HCID 71252161, compoundYield 73.4%

Procedure

Using (S)-4-[1-(1,1-dioxo-1λ6-isothiazolidin-2-yl)ethyl]benzoic acid (162 mg) described in Preparation Example 44 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (143 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 87, the title compound (207 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-082f85f16b2a4fbaa197a3dae78cab22
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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