1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine → HCID 71252170, compound

HRID 2411633Notes

Reaction equation

HRID 2411633 reaction equation
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]1[CH:17]=[CH:16][C:11]([C:12]([O:14]C)=O)=[CH:10][N:9]=1.[CH:19]1([C:22]2[CH:23]=[C:24]([CH3:34])[C:25]([N:28]3[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]3)=[N:26][CH:27]=2)[CH2:21][CH2:20]1>>[CH:19]1([C:22]2[CH:23]=[C:24]([CH3:34])[C:25]([N:28]3[CH2:29][CH2:30][N:31]([C:12]([C:11]4[CH:10]=[N:9][C:8]([CH2:7][N:3]5[CH2:4][CH2:5][CH2:6][S:2]5(=[O:1])=[O:18])=[CH:17][CH:16]=4)=[O:14])[CH2:32][CH2:33]3)=[N:26][CH:27]=2)[CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazineHCID 71252272HCID 71252272, compound

Product 1

HCID 71252170HCID 71252170, compoundYield 85.7%

Procedure

Using methyl 6-(1,1-dioxo-1λ6-isothiazolidin-2-ylmethyl)nicotinate (108 mg) described in Preparation Example 45 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (87 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109, the title compound (156 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-09323f3e7814406aacb920aad5347d22
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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