Cesium carbonate → HCID 71252567, compound

Participants

Reaction Steps

To a mixture of 5-bromo-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile (599 mg) described in Preparation Example 187, isothiazolidine 1,1-dioxide (236 mg), 4,5-bisdiphenylphosphanyl-9,9-dimethyl-9H-xanthene (130 mg), palladium acetate (34 mg) and cesium carbonate (733 mg) was added 1,4-dioxane (2 mL), and the mixture was stirred with heating under reflux for 2 hr. The reaction mixture was cooled, saturated brine was added and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over sodium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by column chromatography (ethyl acetate:hexane) to give the title compound (470 mg).

Provenance & Evidence