1-(3,5-Dimethylpyridin-2-yl)piperazine → HCID 71252103, compound

HRID 2411642Notes

Reaction equation

HRID 2411642 reaction equation
[O:1]=[S:2]1(=[O:18])[NH:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:17]=[CH:16][C:10]([C:11]([O:13]CC)=O)=[CH:9][CH:8]=1.[CH3:19][C:20]1[C:21]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[N:22][CH:23]=[C:24]([CH3:26])[CH:25]=1>>[CH3:19][C:20]1[C:21]([N:27]2[CH2:28][CH2:29][N:30]([C:11]([C:10]3[CH:9]=[CH:8][C:7]([N:3]4[CH2:4][CH2:5][NH:6][S:2]4(=[O:1])=[O:18])=[CH:17][CH:16]=3)=[O:13])[CH2:31][CH2:32]2)=[N:22][CH:23]=[C:24]([CH3:26])[CH:25]=1

Participants

3

Reactant 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazineHCID 71253061HCID 71253061, compound

Product 1

HCID 71252103HCID 71252103, compoundYield 72.9%

Procedure

Using ethyl 4-(1,1-dioxo-1λ6-[1,2,5]thiadiazolidin-2-yl)benzoate (198 mg) described in Preparation Example 46 and 1-(3,5-dimethylpyridin-2-yl)piperazine (141 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109, the title compound (222 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-0db62802b4b34953b0bf279c0c97d482
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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