Methyl iodide → HCID 71251945, compound

HRID 2411643Notes

Reaction equation

[O:1]=[S:2]1(=[O:18])[NH:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:17]=[CH:16][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:9][CH:8]=1.[CH3:19]I>>[CH3:19][N:6]1[S:2](=[O:1])(=[O:18])[N:3]([C:7]2[CH:17]=[CH:16][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:9][CH:8]=2)[CH2:4][CH2:5]1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 71253061HCID 71253061, compound

Product 1

HCID 71251945HCID 71251945, compound

Procedure

Using ethyl 4-(1,1-dioxo-1λ6-[1,2,5]thiadiazolidin-2-yl)benzoate (195 mg) described in Preparation Example 46 and methyl iodide (99 μL) and by the reaction and treatment in the same manner as in Example 36, crude ethyl 4-(5-methyl-1,1-dioxo-1λ6-[1,2,5]thiadiazolidin-2-yl)benzoate (107 mg) was obtained. Using the obtained crude ethyl 4-(5-methyl-1,1-dioxo-1λ6-[1,2,5]thiadiazolidin-2-yl)benzoate (107 mg) and 1-(3,5-dimethylpyridin-2-yl)piperazine (75.7 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109, the title compound (120 mg) was obtained.

Sources & evidence

ORD record: ord-a052c5636d8b419eaad054f8e1efa516
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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