1-(3,5-Dimethylpyridin-2-yl)piperazine → HCID 71252479, compound

HRID 2411644Notes

Reaction equation

HRID 2411644 reaction equation
[O:1]=[S:2]1(=[O:19])[NH:7][CH2:6][CH2:5][CH2:4][N:3]1[C:8]1[CH:18]=[CH:17][C:11]([C:12]([O:14]CC)=O)=[CH:10][CH:9]=1.[CH3:20][C:21]1[C:22]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[N:23][CH:24]=[C:25]([CH3:27])[CH:26]=1>>[CH3:20][C:21]1[C:22]([N:28]2[CH2:29][CH2:30][N:31]([C:12]([C:11]3[CH:10]=[CH:9][C:8]([N:3]4[CH2:4][CH2:5][CH2:6][NH:7][S:2]4(=[O:1])=[O:19])=[CH:18][CH:17]=3)=[O:14])[CH2:32][CH2:33]2)=[N:23][CH:24]=[C:25]([CH3:27])[CH:26]=1

Participants

3

Reactant 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazineHCID 71252681HCID 71252681, compound

Product 1

HCID 71252479HCID 71252479, compoundYield 44.1%

Procedure

Using ethyl 4-(1,1-dioxo-1λ6-[1,2,6]thiadiazinan-2-yl)benzoate (300 mg) described in Preparation Example 47 and 1-(3,5-dimethylpyridin-2-yl)piperazine (202 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109, the title compound (200 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-f4edc7e4ac19453789c38ce68dc5e5dd
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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