Methyl iodide → HCID 71252793, compound

HRID 2411645Notes

Reaction equation

[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:28][CH2:27][CH2:26][NH:25][S:24]4(=[O:30])=[O:29])=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[CH3:31]I>>[CH3:1][C:2]1[C:3]([N:9]2[CH2:10][CH2:11][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:28][CH2:27][CH2:26][N:25]([CH3:31])[S:24]4(=[O:29])=[O:30])=[CH:19][CH:18]=3)=[O:16])[CH2:13][CH2:14]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 71252479HCID 71252479, compound

Product 1

HCID 71252793HCID 71252793, compound

Procedure

Using [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl][4-(1,1-dioxo-1λ6-[1,2,6]thiadiazinan-2-yl)phenyl]methanone (150 mg) described in Example 271 and methyl iodide (24 μL) and by the reaction and treatment in the same manner as in Example 36, the title compound (103 mg) was obtained.

Sources & evidence

ORD record: ord-9b8cc1c3f6284a1ab48291e8202f0a94
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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