5-Methyl-2-pyrrolidone → HCID 71252019, compound

HRID 2411651Notes

Reaction equation

HRID 2411651 reaction equation
[CH3:1][CH:2]1[NH:6][C:5](=[O:7])[CH2:4][CH2:3]1.Br[C:9]1[CH:14]=[CH:13][C:12]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[C:28]([CH3:29])=[CH:27][C:26]([CH3:30])=[CH:25][N:24]=3)[CH2:19][CH2:18]2)=[O:16])=[C:11]([F:31])[CH:10]=1>>[CH3:29][C:28]1[C:23]([N:20]2[CH2:21][CH2:22][N:17]([C:15]([C:12]3[CH:13]=[CH:14][C:9]([N:6]4[CH:2]([CH3:1])[CH2:3][CH2:4][C:5]4=[O:7])=[CH:10][C:11]=3[F:31])=[O:16])[CH2:18][CH2:19]2)=[N:24][CH:25]=[C:26]([CH3:30])[CH:27]=1

Participants

3

Reactant 2

HCID 660555-Methyl-2-pyrrolidoneHCID 58484626(4-Bromo-2-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252019HCID 71252019, compoundYield 42%

Procedure

Using 5-methylpyrrolidin-2-one (54 mg) and (4-bromo-2-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (240 mg) described in Preparation Example 114 and by the reaction and treatment in the same manner as in Example 1, the title compound (94 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 114 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-6d7d94c655634568a4aaa1f9d1869765
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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