2-Pyrrolidone → HCID 71252983, compound

HRID 2411657Notes

Reaction equation

[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].Br[C:8]1[N:13]=[CH:12][C:11]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][C:23]=3[CH3:29])[CH2:18][CH2:17]2)=[O:15])=[CH:10][CH:9]=1>>[CH3:29][C:23]1[CH:24]=[C:25]([CH3:28])[CH:26]=[CH:27][C:22]=1[N:19]1[CH2:18][CH2:17][N:16]([C:14]([C:11]2[CH:10]=[CH:9][C:8]([N:1]3[CH2:5][CH2:4][CH2:3][C:2]3=[O:6])=[N:13][CH:12]=2)=[O:15])[CH2:21][CH2:20]1

Participants

Reactant 2

HCID 120252-Pyrrolidone

HCID 58484755HCID 58484755, compound

Product 1

HCID 71252983HCID 71252983, compoundYield 56.6%

Procedure

Using pyrrolidin-2-one (89 mg) and (6-bromopyridin-3-yl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (374 mg) described in Preparation Example 115 and by the reaction and treatment in the same manner as in Example 1, the title compound (214 mg) was obtained.

Workup

customdescribed in Preparation Example 115 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record: ord-62b637ef3940472a953679f708b4314d
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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