(R)-(-)-5-(Hydroxymethyl)-2-pyrrolidinone → HCID 71253199, compound

HRID 2411658Notes

Reaction equation

HRID 2411658 reaction equation
[OH:1][CH2:2][C@@H:3]1[NH:7][C:6](=[O:8])[CH2:5][CH2:4]1.[CH3:9][C:10]1[C:11]([N:17]2[CH2:22][CH2:21][N:20]([C:23]([C:25]3[CH:30]=[CH:29][C:28](I)=[CH:27][CH:26]=3)=[O:24])[CH2:19][CH2:18]2)=[N:12][CH:13]=[C:14]([CH3:16])[CH:15]=1>>[CH3:9][C:10]1[C:11]([N:17]2[CH2:18][CH2:19][N:20]([C:23]([C:25]3[CH:30]=[CH:29][C:28]([N:7]4[C@@H:3]([CH2:2][OH:1])[CH2:4][CH2:5][C:6]4=[O:8])=[CH:27][CH:26]=3)=[O:24])[CH2:21][CH2:22]2)=[N:12][CH:13]=[C:14]([CH3:16])[CH:15]=1

Participants

3

Reactant 2

HCID 7128291(R)-(-)-5-(Hydroxymethyl)-2-pyrrolidinoneHCID 58484535[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 71253199HCID 71253199, compoundYield 47.6%

Procedure

Using (R)-5-hydroxymethylpyrrolidin-2-one (137 mg) and [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (500 mg) described in Preparation Example 113 and by the reaction and treatment in the same manner as in Example 1, the title compound (231 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 113 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-7ae0d8fddd4546928c57d8634c76ca3f
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…