HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-(-)-5-(Hydroxymethyl)-2-pyrrolidinone → HCID 71252545, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-(-)-5-(Hydroxymethyl)-2-pyrrolidinone | HCID 7128291 | — |
| Reactant | (4-Bromo-2,6-difluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484761 | — |
| Product | HCID 71252545 | HCID 71252545 | 47.3% |
Reaction Steps
Using (R)-5-hydroxymethylpyrrolidin-2-one (116 mg) and (4-bromo-2,6-difluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (410 mg) described in Preparation Example 111 and by the reaction and treatment in the same manner as in Example 1, the title compound (210 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-6acbe2ddbfbd4af99ef7cd9ac4a10c85 |
| Source note | uspto-grants-2014_08 |