HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-5-(Hydroxymethyl)-2-pyrrolidinone → (S)-1-{4-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-5-hydroxymethylpyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-5-(Hydroxymethyl)-2-pyrrolidinone | HCID 643511 | — |
| Reactant | HCID 71251940 | HCID 71251940 | — |
| Product | (S)-1-{4-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-5-hydroxymethylpyrrolidin-2-one | HCID 71252866 | 40.6% |
Reaction Steps
Using (S)-5-hydroxymethylpyrrolidin-2-one (94 mg) and [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl](2-fluoro-4-iodophenyl)methanone (400 mg) described in Preparation Example 164 and by the reaction and treatment in the same manner as in Example 1, the title compound (158 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-ff1abea1a40e4f1f8288359dd6d42fbb |
| Source note | uspto-grants-2014_08 |