2-Pyrrolidone → HCID 71251876, compound

HRID 2411669Notes

Reaction equation

HRID 2411669 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].Br[C:8]1[CH:13]=[CH:12][C:11]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([CH3:28])=[CH:26][C:25]([CH:29]4[CH2:31][CH2:30]4)=[CH:24][N:23]=3)[CH2:18][CH2:17]2)=[O:15])=[C:10]([F:32])[CH:9]=1>>[CH:29]1([C:25]2[CH:26]=[C:27]([CH3:28])[C:22]([N:19]3[CH2:18][CH2:17][N:16]([C:14]([C:11]4[CH:12]=[CH:13][C:8]([N:1]5[CH2:5][CH2:4][CH2:3][C:2]5=[O:6])=[CH:9][C:10]=4[F:32])=[O:15])[CH2:21][CH2:20]3)=[N:23][CH:24]=2)[CH2:30][CH2:31]1

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 58484842(4-Bromo-2-fluorophenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71251876HCID 71251876, compoundYield 73%

Procedure

Using pyrrolidin-2-one (94 mg) and (4-bromo-2-fluorophenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (418 mg) described in Preparation Example 121 and by the reaction and treatment in the same manner as in Example 1, the title compound (308 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 121 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-a137f87f35d249a8be06b0811bb96117
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…