2-Pyrrolidone → HCID 71252913, compound

HRID 2411670Notes

Reaction equation

HRID 2411670 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].Br[C:8]1[CH:13]=[CH:12][C:11]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([CH3:28])=[CH:26][C:25]([CH3:29])=[CH:24][N:23]=3)[CH2:18][CH2:17]2)=[O:15])=[C:10]([CH3:30])[CH:9]=1>>[CH3:28][C:27]1[C:22]([N:19]2[CH2:18][CH2:17][N:16]([C:14]([C:11]3[CH:12]=[CH:13][C:8]([N:1]4[CH2:5][CH2:4][CH2:3][C:2]4=[O:6])=[CH:9][C:10]=3[CH3:30])=[O:15])[CH2:21][CH2:20]2)=[N:23][CH:24]=[C:25]([CH3:29])[CH:26]=1

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 58484835(4-Bromo-2-methylphenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252913HCID 71252913, compoundYield 44.9%

Procedure

Using pyrrolidin-2-one (47 mg) and (4-bromo-2-methylphenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (194 mg) described in Preparation Example 118 and by the reaction and treatment in the same manner as in Example 1, the title compound (88 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 118 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-c5fb09b05baf41a4b382097757388352
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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