HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-5-(Hydroxymethyl)-2-pyrrolidinone → HCID 71252443, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-5-(Hydroxymethyl)-2-pyrrolidinone | HCID 643511 | — |
| Reactant | (4-Bromo-2-methylphenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484835 | — |
| Product | HCID 71252443 | HCID 71252443 | 17.6% |
Reaction Steps
Using (S)-5-hydroxymethylpyrrolidin-2-one (168 mg) and (4-bromo-2-methylphenyl) [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (516 mg) described in Preparation Example 118 and by the reaction and treatment in the same manner as in Example 1, the title compound (99 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-8069f780aa9e4b31941ed00d87cbeecb |
| Source note | uspto-grants-2014_08 |