(S)-5-(Hydroxymethyl)-2-pyrrolidinone → HCID 71252492, compound

HRID 2411677Notes

Reaction equation

HRID 2411677 reaction equation
[OH:1][CH2:2][C@H:3]1[NH:7][C:6](=[O:8])[CH2:5][CH2:4]1.Br[C:10]1[CH:15]=[CH:14][C:13]([C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH3:30])=[CH:28][C:27]([CH:31]4[CH2:33][CH2:32]4)=[CH:26][N:25]=3)[CH2:20][CH2:19]2)=[O:17])=[C:12]([CH3:34])[CH:11]=1>>[CH:31]1([C:27]2[CH:28]=[C:29]([CH3:30])[C:24]([N:21]3[CH2:22][CH2:23][N:18]([C:16]([C:13]4[CH:14]=[CH:15][C:10]([N:7]5[C@H:3]([CH2:2][OH:1])[CH2:4][CH2:5][C:6]5=[O:8])=[CH:11][C:12]=4[CH3:34])=[O:17])[CH2:19][CH2:20]3)=[N:25][CH:26]=2)[CH2:32][CH2:33]1

Participants

3

Reactant 2

HCID 643511(S)-5-(Hydroxymethyl)-2-pyrrolidinoneHCID 58484636(4-Bromo-2-methylphenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252492HCID 71252492, compoundYield 33.8%

Procedure

Using (S)-5-hydroxymethylpyrrolidin-2-one (153 mg) and (4-bromo-2-methylphenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (500 mg) described in Preparation Example 124 and by the reaction and treatment in the same manner as in Example 1, the title compound (183 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 124 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-a746e64e14f1446684f17f05e90da344
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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