2-Pyrrolidone → 1-{3-Fluoro-4-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}pyrrolidin-2-one

HRID 2411678Notes

Reaction equation

HRID 2411678 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].Br[C:8]1[CH:13]=[CH:12][C:11]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([CH3:28])=[CH:26][C:25]([CH3:29])=[C:24]([CH3:30])[N:23]=3)[CH2:18][CH2:17]2)=[O:15])=[C:10]([F:31])[CH:9]=1>>[F:31][C:10]1[CH:9]=[C:8]([N:1]2[CH2:5][CH2:4][CH2:3][C:2]2=[O:6])[CH:13]=[CH:12][C:11]=1[C:14]([N:16]1[CH2:17][CH2:18][N:19]([C:22]2[C:27]([CH3:28])=[CH:26][C:25]([CH3:29])=[C:24]([CH3:30])[N:23]=2)[CH2:20][CH2:21]1)=[O:15]

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 58484847(4-Bromo-2-fluorophenyl) [4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 712525421-{3-Fluoro-4-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}pyrrolidin-2-oneYield 89.7%

Procedure

Using pyrrolidin-2-one (94 mg) and (4-bromo-2-fluorophenyl) [4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (406 mg) described in Preparation Example 128 and by the reaction and treatment in the same manner as in Example 1, the title compound (368 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 128 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-8c8f2456fb2748f9bfcd3ae348c36f7e
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…