2-Pyrrolidone → HCID 71252231, compound

HRID 2411681Notes

Reaction equation

HRID 2411681 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].I[C:8]1[CH:13]=[CH:12][C:11]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([CH3:28])=[CH:26][C:25]([CH3:29])=[C:24]([CH3:30])[N:23]=3)[CH2:18][CH2:17]2)=[O:15])=[CH:10][CH:9]=1>>[CH3:28][C:27]1[C:22]([N:19]2[CH2:20][CH2:21][N:16]([C:14]([C:11]3[CH:12]=[CH:13][C:8]([N:1]4[CH2:5][CH2:4][CH2:3][C:2]4=[O:6])=[CH:9][CH:10]=3)=[O:15])[CH2:17][CH2:18]2)=[N:23][C:24]([CH3:30])=[C:25]([CH3:29])[CH:26]=1

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 58484793(4-Iodophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252231HCID 71252231, compoundYield 59.7%

Procedure

Using pyrrolidin-2-one (94 mg) and (4-iodophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (435 mg) described in Preparation Example 120 and by the reaction and treatment in the same manner as in Example 1, the title compound (234 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 120 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-0aaeee7c805143cb80d045439c16ad28
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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