2-Pyrrolidone → 1-{3-Chloro-4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}pyrrolidin-2-one

HRID 2411683Notes

Reaction equation

HRID 2411683 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].Br[C:8]1[CH:13]=[CH:12][C:11]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([CH3:28])=[CH:26][C:25]([CH3:29])=[CH:24][N:23]=3)[CH2:18][CH2:17]2)=[O:15])=[C:10]([Cl:30])[CH:9]=1>>[Cl:30][C:10]1[CH:9]=[C:8]([N:1]2[CH2:5][CH2:4][CH2:3][C:2]2=[O:6])[CH:13]=[CH:12][C:11]=1[C:14]([N:16]1[CH2:17][CH2:18][N:19]([C:22]2[C:27]([CH3:28])=[CH:26][C:25]([CH3:29])=[CH:24][N:23]=2)[CH2:20][CH2:21]1)=[O:15]

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 58484833(4-Bromo-2-chlorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 712519711-{3-Chloro-4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}pyrrolidin-2-oneYield 66.3%

Procedure

Using pyrrolidin-2-one (23 mg) and (4-bromo-2-chlorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (100 mg) described in Preparation Example 119 and by the reaction and treatment in the same manner as in Example 1, the title compound (67 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 119 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-071fe15e617d4a47bab7dec7b1ca6184
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…