2-Pyrrolidone → HCID 71252569, compound

HRID 2411685Notes

Reaction equation

[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].Br[C:8]1[CH:9]=[CH:10][C:11]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([CH3:28])=[CH:26][C:25]([CH3:29])=[CH:24][N:23]=3)[CH2:18][CH2:17]2)=[O:15])=[N:12][CH:13]=1>>[CH3:28][C:27]1[C:22]([N:19]2[CH2:20][CH2:21][N:16]([C:14]([C:11]3[N:12]=[CH:13][C:8]([N:1]4[CH2:5][CH2:4][CH2:3][C:2]4=[O:6])=[CH:9][CH:10]=3)=[O:15])[CH2:17][CH2:18]2)=[N:23][CH:24]=[C:25]([CH3:29])[CH:26]=1

Participants

Reactant 2

HCID 120252-Pyrrolidone

HCID 58484566HCID 58484566, compound

Product 1

HCID 71252569HCID 71252569, compoundYield 71.7%

Procedure

Using pyrrolidin-2-one (94 mg) and (5-bromopyridin-2-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (375 mg) described in Preparation Example 134 and by the reaction and treatment in the same manner as in Example 1, the title compound (272 mg) was obtained.

Workup

customdescribed in Preparation Example 134 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record: ord-fd7b552283c44258b05843843708a1c0
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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