2-Pyrrolidone → HCID 71252456, compound

HRID 2411687Notes

Reaction equation

[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].Br[C:8]1[N:13]=[CH:12][C:11]([C:14]([N:16]2[CH2:21][CH2:20][CH:19]([O:22][C:23]3[CH:28]=[CH:27][C:26]([CH:29]4[CH2:31][CH2:30]4)=[CH:25][CH:24]=3)[CH2:18][CH2:17]2)=[O:15])=[CH:10][CH:9]=1>>[CH:29]1([C:26]2[CH:27]=[CH:28][C:23]([O:22][CH:19]3[CH2:18][CH2:17][N:16]([C:14]([C:11]4[CH:10]=[CH:9][C:8]([N:1]5[CH2:5][CH2:4][CH2:3][C:2]5=[O:6])=[N:13][CH:12]=4)=[O:15])[CH2:21][CH2:20]3)=[CH:24][CH:25]=2)[CH2:30][CH2:31]1

Participants

Reactant 2

HCID 120252-Pyrrolidone

HCID 58484616HCID 58484616, compound

Product 1

HCID 71252456HCID 71252456, compoundYield 58.7%

Procedure

Using pyrrolidin-2-one (94 mg) and (6-bromopyridin-3-yl)[4-(4-cyclopropylphenoxy)piperidin-1-yl]methanone (401 mg) described in Preparation Example 192 and by the reaction and treatment in the same manner as in Example 1, the title compound (238 mg) was obtained.

Workup

customdescribed in Preparation Example 192 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record: ord-acaedc029930457c81c28835386cbf2a
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

Loading…