2-Pyrrolidone → 1-{5-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}pyrrolidin-2-one

HRID 2411688Notes

Reaction equation

HRID 2411688 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].Br[C:8]1[N:13]=[CH:12][C:11]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([CH:28]4[CH2:30][CH2:29]4)=[CH:26][C:25]([CH:31]4[CH2:33][CH2:32]4)=[CH:24][N:23]=3)[CH2:18][CH2:17]2)=[O:15])=[CH:10][CH:9]=1>>[CH:28]1([C:27]2[C:22]([N:19]3[CH2:18][CH2:17][N:16]([C:14]([C:11]4[CH:10]=[CH:9][C:8]([N:1]5[CH2:5][CH2:4][CH2:3][C:2]5=[O:6])=[N:13][CH:12]=4)=[O:15])[CH2:21][CH2:20]3)=[N:23][CH:24]=[C:25]([CH:31]3[CH2:33][CH2:32]3)[CH:26]=2)[CH2:29][CH2:30]1

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 58484777(6-Bromopyridin-3-yl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 712523511-{5-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}pyrrolidin-2-oneYield 48.7%

Procedure

Using pyrrolidin-2-one (94 mg) and (6-bromopyridin-3-yl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone (427 mg) described in Preparation Example 143 and by the reaction and treatment in the same manner as in Example 1, the title compound (210 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 143 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-2ec1161320e741c391c5e4a368340c64
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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