2-Pyrrolidone → HCID 71252171, compound

HRID 2411689Notes

Reaction equation

HRID 2411689 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].Br[C:8]1[N:13]=[CH:12][C:11]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([CH3:28])=[CH:26][C:25]([CH:29]4[CH2:31][CH2:30]4)=[CH:24][N:23]=3)[CH2:18][CH2:17]2)=[O:15])=[CH:10][CH:9]=1>>[CH:29]1([C:25]2[CH:26]=[C:27]([CH3:28])[C:22]([N:19]3[CH2:20][CH2:21][N:16]([C:14]([C:11]4[CH:10]=[CH:9][C:8]([N:1]5[CH2:5][CH2:4][CH2:3][C:2]5=[O:6])=[N:13][CH:12]=4)=[O:15])[CH2:17][CH2:18]3)=[N:23][CH:24]=2)[CH2:30][CH2:31]1

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 58484858(6-Bromopyridin-3-yl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252171HCID 71252171, compoundYield 4.5%

Procedure

Using pyrrolidin-2-one (130 mg) and (6-bromopyridin-3-yl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (554 mg) described in Preparation Example 144 and by the reaction and treatment in the same manner as in Example 1, the title compound (25 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 144 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-3dab6c0f997c40c385943886b01d7ef0
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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