5-Methyl-2-pyrrolidone → HCID 71252660, compound

HRID 2411691Notes

Reaction equation

HRID 2411691 reaction equation
[CH3:1][CH:2]1[NH:6][C:5](=[O:7])[CH2:4][CH2:3]1.Br[C:9]1[N:14]=[CH:13][C:12]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[C:28]([CH3:29])=[CH:27][C:26]([CH3:30])=[CH:25][N:24]=3)[CH2:19][CH2:18]2)=[O:16])=[CH:11][CH:10]=1>>[CH3:29][C:28]1[C:23]([N:20]2[CH2:21][CH2:22][N:17]([C:15]([C:12]3[CH:11]=[CH:10][C:9]([N:6]4[CH:2]([CH3:1])[CH2:3][CH2:4][C:5]4=[O:7])=[N:14][CH:13]=3)=[O:16])[CH2:18][CH2:19]2)=[N:24][CH:25]=[C:26]([CH3:30])[CH:27]=1

Participants

3

Reactant 2

HCID 660555-Methyl-2-pyrrolidoneHCID 58484661(6-Bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252660HCID 71252660, compoundYield 43.5%

Procedure

Using 5-methylpyrrolidin-2-one (99 mg) and (6-bromopyridin-3-yl) [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (375 mg) described in Preparation Example 127 and by the reaction and treatment in the same manner as in Example 1, the title compound (171 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 127 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-e7a946f1202d4e79873c91084323cb70
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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