5-Methyl-2-pyrrolidone → HCID 71252203, compound

HRID 2411692Notes

Reaction equation

HRID 2411692 reaction equation
[CH3:1][CH:2]1[NH:6][C:5](=[O:7])[CH2:4][CH2:3]1.Br[C:9]1[N:14]=[CH:13][C:12]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[CH:27][C:26]([CH3:29])=[CH:25][C:24]=3[CH3:30])[CH2:19][CH2:18]2)=[O:16])=[CH:11][CH:10]=1>>[CH3:30][C:24]1[CH:25]=[C:26]([CH3:29])[CH:27]=[CH:28][C:23]=1[N:20]1[CH2:19][CH2:18][N:17]([C:15]([C:12]2[CH:11]=[CH:10][C:9]([N:6]3[CH:2]([CH3:1])[CH2:3][CH2:4][C:5]3=[O:7])=[N:14][CH:13]=2)=[O:16])[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 660555-Methyl-2-pyrrolidoneHCID 58484755HCID 58484755, compound

Product 1

HCID 71252203HCID 71252203, compoundYield 44.9%

Procedure

Using 5-methylpyrrolidin-2-one (99 mg) and (6-bromopyridin-3-yl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (374 mg) described in Preparation Example 115 and by the reaction and treatment in the same manner as in Example 1, the title compound (176 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 115 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-b0a2d63b52c34bb4a1e4aaae0558d3b6
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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