5-Methyl-2-pyrrolidone → HCID 71252850, compound

HRID 2411696Notes

Reaction equation

HRID 2411696 reaction equation
[CH3:1][CH:2]1[NH:6][C:5](=[O:7])[CH2:4][CH2:3]1.Br[C:9]1[N:14]=[CH:13][C:12]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[C:28]([CH3:29])=[CH:27][C:26]([CH:30]4[CH2:32][CH2:31]4)=[CH:25][N:24]=3)[CH2:19][CH2:18]2)=[O:16])=[CH:11][CH:10]=1>>[CH:30]1([C:26]2[CH:27]=[C:28]([CH3:29])[C:23]([N:20]3[CH2:21][CH2:22][N:17]([C:15]([C:12]4[CH:11]=[CH:10][C:9]([N:6]5[CH:2]([CH3:1])[CH2:3][CH2:4][C:5]5=[O:7])=[N:14][CH:13]=4)=[O:16])[CH2:18][CH2:19]3)=[N:24][CH:25]=2)[CH2:31][CH2:32]1

Participants

3

Reactant 2

HCID 660555-Methyl-2-pyrrolidoneHCID 58484858(6-Bromopyridin-3-yl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252850HCID 71252850, compoundYield 24.4%

Procedure

Using 5-methylpyrrolidin-2-one (64 mg) and (6-bromopyridin-3-yl) [4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (260 mg) described in Preparation Example 144 and by the reaction and treatment in the same manner as in Example 1, the title compound (66 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 144 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-20f674d85156427f8854bb2424612c44
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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