HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methyl-2-pyrrolidone → 1-{5-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-5-methylpyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methyl-2-pyrrolidone | HCID 66055 | — |
| Reactant | (6-Bromopyridin-3-yl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484777 | — |
| Product | 1-{5-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-5-methylpyrrolidin-2-one | HCID 71252309 | 2,987.4% |
Reaction Steps
Using 5-methylpyrrolidin-2-one (99 mg) and (6-bromopyridin-3-yl) [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone (4.27 mg) described in Preparation Example 143 and by the reaction and treatment in the same manner as in Example 1, the title compound (133 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-9f67d927b1124cbdbed913eec9df42b6 |
| Source note | uspto-grants-2014_08 |