2-Piperidone → HCID 71252543, compound

HRID 2411698Notes

Reaction equation

HRID 2411698 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][C:2]1=[O:7].Br[C:9]1[CH:14]=[C:13]([F:15])[C:12]([C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH3:30])=[CH:28][C:27]([CH3:31])=[CH:26][N:25]=3)[CH2:20][CH2:19]2)=[O:17])=[C:11]([F:32])[CH:10]=1>>[CH3:30][C:29]1[C:24]([N:21]2[CH2:22][CH2:23][N:18]([C:16]([C:12]3[C:13]([F:15])=[CH:14][C:9]([N:1]4[CH2:6][CH2:5][CH2:4][CH2:3][C:2]4=[O:7])=[CH:10][C:11]=3[F:32])=[O:17])[CH2:19][CH2:20]2)=[N:25][CH:26]=[C:27]([CH3:31])[CH:28]=1

Participants

3

Reactant 2

HCID 126652-PiperidoneHCID 58484761(4-Bromo-2,6-difluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252543HCID 71252543, compoundYield 48.4%

Procedure

Using piperidin-2-one (51 mg) and (4-bromo-2,6-difluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (200 mg) described in Preparation Example 111 and by the reaction and treatment in the same manner as in Example 1, the title compound (101 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 111 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-f3acdb48cfaa40a2af7dce98c286460b
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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