2-Piperidone → HCID 71252107, compound

HRID 2411699Notes

Reaction equation

HRID 2411699 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][C:2]1=[O:7].Br[C:9]1[CH:14]=[CH:13][C:12]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[CH:27][C:26]([CH3:29])=[CH:25][C:24]=3[CH3:30])[CH2:19][CH2:18]2)=[O:16])=[C:11]([S:31]([CH3:34])(=[O:33])=[O:32])[CH:10]=1>>[CH3:30][C:24]1[CH:25]=[C:26]([CH3:29])[CH:27]=[CH:28][C:23]=1[N:20]1[CH2:19][CH2:18][N:17]([C:15]([C:12]2[CH:13]=[CH:14][C:9]([N:1]3[CH2:6][CH2:5][CH2:4][CH2:3][C:2]3=[O:7])=[CH:10][C:11]=2[S:31]([CH3:34])(=[O:33])=[O:32])=[O:16])[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 126652-PiperidoneHCID 58484856(4-Bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone

Product 1

HCID 71252107HCID 71252107, compoundYield 62.4%

Procedure

Using piperidin-2-one (104 mg) and (4-bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (451 mg) described in Preparation Example 110 and by the reaction and treatment in the same manner as in Example 1, the title compound (293 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 110 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-a77223a7a7af4f63a889c2e71bf0874a
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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