2-Piperidone → HCID 71252460, compound

HRID 2411700Notes

Reaction equation

HRID 2411700 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][C:2]1=[O:7].Br[C:9]1[N:14]=[CH:13][C:12]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[C:28]([CH3:29])=[CH:27][C:26]([CH3:30])=[CH:25][N:24]=3)[CH2:19][CH2:18]2)=[O:16])=[CH:11][CH:10]=1>>[CH3:29][C:28]1[C:23]([N:20]2[CH2:21][CH2:22][N:17]([C:15]([C:12]3[CH:11]=[CH:10][C:9]([N:1]4[CH2:6][CH2:5][CH2:4][CH2:3][C:2]4=[O:7])=[N:14][CH:13]=3)=[O:16])[CH2:18][CH2:19]2)=[N:24][CH:25]=[C:26]([CH3:30])[CH:27]=1

Participants

3

Reactant 2

HCID 126652-PiperidoneHCID 58484661(6-Bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252460HCID 71252460, compoundYield 20%

Procedure

Using piperidin-2-one (58 mg) and (6-bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (200 mg) described in Preparation Example 127 and by the reaction and treatment in the same manner as in Example 1, the title compound (42 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 127 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-f99cd6f4171b47ed900a7f212c16a10e
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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