2-Piperidone → HCID 71252398, compound

HRID 2411701Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][C:2]1=[O:7].Br[C:9]1[N:14]=[CH:13][C:12]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[C:28]([CH3:29])=[CH:27][C:26]([CH:30]4[CH2:32][CH2:31]4)=[CH:25][N:24]=3)[CH2:19][CH2:18]2)=[O:16])=[CH:11][CH:10]=1>>[CH:30]1([C:26]2[CH:27]=[C:28]([CH3:29])[C:23]([N:20]3[CH2:21][CH2:22][N:17]([C:15]([C:12]4[CH:11]=[CH:10][C:9]([N:1]5[CH2:6][CH2:5][CH2:4][CH2:3][C:2]5=[O:7])=[N:14][CH:13]=4)=[O:16])[CH2:18][CH2:19]3)=[N:24][CH:25]=2)[CH2:31][CH2:32]1

Participants

Reactant 2

HCID 126652-Piperidone

HCID 58484858(6-Bromopyridin-3-yl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252398HCID 71252398, compoundYield 38.3%

Procedure

Using piperidin-2-one (14 mg) and (6-bromopyridin-3-yl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (50 mg) described in Preparation Example 144 and by the reaction and treatment in the same manner as in Example 1, the title compound (20 mg) was obtained.

Workup

customdescribed in Preparation Example 144 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record: ord-b39572cf400b4135b54a4d5660f4b03a
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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