4-Morpholinopiperidine → HCID 71252248, compound

HRID 2411705Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[CH:22]=[CH:21][C:20]([N:23]3[C:27](=[O:28])[CH2:26][CH:25]([C:29]([OH:31])=O)[CH2:24]3)=[CH:19][CH:18]=2)=[O:16])[CH2:11][CH2:10]1.[O:32]1[CH2:37][CH2:36][N:35]([CH:38]2[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]2)[CH2:34][CH2:33]1>>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[CH:22]=[CH:21][C:20]([N:23]3[CH2:24][CH:25]([C:29]([N:41]4[CH2:42][CH2:43][CH:38]([N:35]5[CH2:36][CH2:37][O:32][CH2:33][CH2:34]5)[CH2:39][CH2:40]4)=[O:31])[CH2:26][C:27]3=[O:28])=[CH:19][CH:18]=2)=[O:16])[CH2:11][CH2:10]1

Participants

Reactant 2

HCID 7957244-Morpholinopiperidine

HCID 71252355HCID 71252355, compound

Product 1

HCID 71252248HCID 71252248, compoundYield 62.4%

Procedure

Using 1-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]phenyl}-5-oxopyrrolidine-3-carboxylic acid (100 mg) described in Example 333 and 4-morpholinopiperidine (44 mg) and by the reaction and treatment in the same manner as in Example 87, the title compound (85 mg) was obtained.

Sources & evidence

ORD record: ord-f6c1adfbefef43ecac8ee3663abeed17
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

Loading…