(3S)-(-)-3-(Dimethylamino)pyrrolidine → HCID 71252371, compound

HRID 2411706Notes

Reaction equation

HRID 2411706 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[CH:22]=[CH:21][C:20]([N:23]3[C:27](=[O:28])[CH2:26][CH:25]([C:29]([OH:31])=O)[CH2:24]3)=[CH:19][CH:18]=2)=[O:16])[CH2:11][CH2:10]1.[CH3:32][N:33]([CH3:39])[C@H:34]1[CH2:38][CH2:37][NH:36][CH2:35]1>>[CH3:32][N:33]([CH3:39])[C@H:34]1[CH2:38][CH2:37][N:36]([C:29]([CH:25]2[CH2:24][N:23]([C:20]3[CH:19]=[CH:18][C:17]([C:15]([N:12]4[CH2:13][CH2:14][N:9]([C:3]5[CH:4]=[CH:5][C:6]([CH3:8])=[CH:7][C:2]=5[CH3:1])[CH2:10][CH2:11]4)=[O:16])=[CH:22][CH:21]=3)[C:27](=[O:28])[CH2:26]2)=[O:31])[CH2:35]1

Participants

3

Reactant 2

HCID 7019156(3S)-(-)-3-(Dimethylamino)pyrrolidineHCID 71252355HCID 71252355, compound

Product 1

HCID 71252371HCID 71252371, compoundYield 39.2%

Procedure

Using 1-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]phenyl}-5-oxopyrrolidine-3-carboxylic acid (100 mg) described in Example 333 and (S)-3-(dimethylamino)pyrrolidine (27 mg) and by the reaction and treatment in the same manner as in Example 87, the title compound (48 mg) was obtained.

Sources & evidence

ORD record
ord-cf5c6e4e1dc7467fa41df02253ceb8aa
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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