Methanol → HCID 71251997, compound

Participants

Reaction Steps

To 1-{4-[4-(2,4-dimethylphenyl)piperazine-carbonyl]phenyl}-5-oxopyrrolidine-3-carboxylic acid methyl ester (1.3 g) described in Example 337 were added tetrahydrofuran (5 mL) and sodium borohydride (124 mg), methanol (0.9 mL) was added with heating under reflux, and the mixture was stirred for 1 hr. The reaction mixture was cooled, water was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and the solvent was evaporated. The obtained residue was purified by column chromatography (chloroform:methanol) to give the title compound (1.06 g).

Provenance & Evidence