(s)-3-Fluoropyrrolidine hydrochloride → HCID 71252624, compound

HRID 2411710Notes

Reaction equation

HRID 2411710 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[CH:22]=[CH:21][C:20]([N:23]3[C:27](=[O:28])[CH2:26][CH:25]([C:29]([OH:31])=O)[CH2:24]3)=[CH:19][CH:18]=2)=[O:16])[CH2:11][CH2:10]1.Cl.[F:33][C@H:34]1[CH2:38][CH2:37][NH:36][CH2:35]1>>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:10][CH2:11][N:12]([C:15]([C:17]2[CH:22]=[CH:21][C:20]([N:23]3[CH2:24][CH:25]([C:29]([N:36]4[CH2:37][CH2:38][C@H:34]([F:33])[CH2:35]4)=[O:31])[CH2:26][C:27]3=[O:28])=[CH:19][CH:18]=2)=[O:16])[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 16217739(s)-3-Fluoropyrrolidine hydrochlorideHCID 71252355HCID 71252355, compound

Product 1

HCID 71252624HCID 71252624, compoundYield 17.9%

Procedure

Using 1-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]phenyl}-5-oxopyrrolidine-3-carboxylic acid (62 mg) described in Example 333 and (S)-3-fluoropyrrolidine hydrochloride (19 mg) and by the reaction and treatment in the same manner as in Example 86, the title compound (13 mg) was obtained.

Sources & evidence

ORD record
ord-85f2a96dc061448b9068c21ef4f8d7bb
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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