HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-5-(Hydroxymethyl)-2-pyrrolidinone → (S)-1-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]phenyl}-5-hydroxymethylpyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-5-(Hydroxymethyl)-2-pyrrolidinone | HCID 643511 | — |
| Reactant | (4-Bromophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone | HCID 58484623 | — |
| Product | (S)-1-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]phenyl}-5-hydroxymethylpyrrolidin-2-one | HCID 71252249 | 50.8% |
Reaction Steps
Using (4-bromophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (1.87 g) described in Preparation Example 170 and (S)-5-hydroxymethylpyrrolidin-2-one (556 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (1.00 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-cc597919f7d840b6958067e13560fc50 |
| Source note | uspto-grants-2014_08 |