1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine → HCID 71252541, compound

HRID 2411716Notes

Reaction equation

HRID 2411716 reaction equation
[CH3:1][CH:2]1[CH2:6][N:5]([C:7]2[CH:17]=[CH:16][C:10]([C:11]([O:13]CC)=O)=[CH:9][CH:8]=2)[C:4](=[O:18])[CH2:3]1.[CH:19]1([C:22]2[CH:23]=[C:24]([CH3:34])[C:25]([N:28]3[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]3)=[N:26][CH:27]=2)[CH2:21][CH2:20]1>>[CH:19]1([C:22]2[CH:23]=[C:24]([CH3:34])[C:25]([N:28]3[CH2:29][CH2:30][N:31]([C:11]([C:10]4[CH:9]=[CH:8][C:7]([N:5]5[CH2:6][CH:2]([CH3:1])[CH2:3][C:4]5=[O:18])=[CH:17][CH:16]=4)=[O:13])[CH2:32][CH2:33]3)=[N:26][CH:27]=2)[CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazineHCID 71252710HCID 71252710, compound

Product 1

HCID 71252541HCID 71252541, compoundYield 22.9%

Procedure

Using ethyl 4-(4-methyl-2-oxopyrrolidin-1-yl)benzoate (124 mg) described in Preparation Example 48 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (109 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109, the title compound (48 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-ad790a44c4a948219e2f062eba88436c
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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