1-(3,5-Dimethylpyridin-2-yl)piperazine → HCID 71252381, compound

HRID 2411717Notes

Reaction equation

HRID 2411717 reaction equation
[CH3:1][C:2]1([CH3:19])[CH2:6][N:5]([C:7]2[CH:17]=[CH:16][C:10]([C:11]([O:13]CC)=O)=[CH:9][CH:8]=2)[C:4](=[O:18])[CH2:3]1.[CH3:20][C:21]1[C:22]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[N:23][CH:24]=[C:25]([CH3:27])[CH:26]=1>>[CH3:20][C:21]1[C:22]([N:28]2[CH2:29][CH2:30][N:31]([C:11]([C:10]3[CH:9]=[CH:8][C:7]([N:5]4[CH2:6][C:2]([CH3:1])([CH3:19])[CH2:3][C:4]4=[O:18])=[CH:17][CH:16]=3)=[O:13])[CH2:32][CH2:33]2)=[N:23][CH:24]=[C:25]([CH3:27])[CH:26]=1

Participants

3

Reactant 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazineHCID 71252759HCID 71252759, compound

Product 1

HCID 71252381HCID 71252381, compoundYield 65.8%

Procedure

Using ethyl 4-(4,4-dimethyl-2-oxopyrrolidin-1-yl)benzoate (131 mg) described in Preparation Example 49 and 1-(3,5-dimethylpyridin-2-yl)piperazine (96 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109, the title compound (134 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-827d63539dfa45079b8083c5855cf0f5
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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